E ect of In iximab Induction erapy on Secondary Systemic Amyloidosis Associated with Crohn’s Disease: Case Report and Review of the Literature

C r o h n’s d i s e a s e ( C D ) is a heterogeneous, chronic in ammatory disease primarily affecting the gastrointestinal tract. Secondary systemic (AA) amyloidosis is a rare but serious complication and a major cause of death in patients with CD setting long-term mortality between 40% and 60% [1-3]. Renal involvement is the most common manifestation of AA amyloidosis, ranging from nephrotic syndrome to renal failure. Multiple organ damage results from the extracellular dep os it ion of proteolyt ic fragments of the acute-phase reactant serum amyloid A (SAA) as amyloid brils [4]. ABSTRACT